Killhope Burn is a stream in County Durham, which is a tributary of the River Wear. The burn is 13 km long, with a catchment area of 28 km2. The burn is formed from a number of small streams draining off Slate Hill, Killhope Moor, Knoutberry Hill, near the county borders with Cumbria, Northumberland and County Durham. The Burn flows roughly south-eastwards past Killhope Lead Mine (now a museum), and the settlements of Lanehead, Cornriggs, Copthill, Cowshill and on to Wearhead. The River Wear forms at the confluence of Killhope Burn and Burnhope Burn at Wearhead.